Researchers uncovered 1,307 genetic loci linked to metabolic syndrome, revealing brain tissue enrichment and key genetic factors in its development. The study also shows polygenic risk scores predict metabolic syndrome across populations.
By Dr. Sushama R. Chaphalkar, PhD.Reviewed by Susha Cheriyedath, M.Sc.Oct 1 2024 New research uncovers over 1,300 genetic loci driving metabolic syndrome , revealing links to brain tissues and offering insights for tailored health strategies across populations.
The research identified 25 gene sets linked to metabolic syndrome, many of which are involved in neuronal, lipid metabolism, and molecular signaling pathways, expanding the biological understanding of MetS. In the present study, researchers analyzed the shared genetic architecture of MetS in a large European cohort, identifying key genetic links through genomic SEM, gene prioritization, and polygenic risk score analysis across multiple populations while also exploring associations with various health outcomes.
Additionally, a multivariate GWAS was performed to uncover SNP associations with MetS factors, and gene prioritization was achieved through functional mapping. Finally, PRS and two-sample Mendelian randomization were applied to assess causal relationships between MetS and other health outcomes, supported by a cross-population comparison using East Asian data.
Genetic Metabolic Syndrome Syndrome Allele Cardiovascular Disease Dyslipidemia Fatty Liver Gene Genes Genetics Genome Genomic Glucose Insulin Insulin Resistance Liver Liver Disease Metabolism Obesity Research
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