Variants of the APBA1 gene are associated with increased obesity risk, according to a study. The study also identifies two genes with the most profound impact on obesity risk at a population level. Previous genetic variants associated with obesity are linked to brain pathways involved in appetite regulation, but the BSN and APBA1 genes are not involved in those pathways. Instead, they play a role in signal transmission between brain cells, suggesting a potential link between age-related brain declines and appetite control.
Variants of the APBA1 gene also are associated with increased obesity risk , results show. “We have identified two genes with variants that have the most profound impact on obesity risk at a population level we've ever seen,” said researcher Giles Yeo, a professor with the Medical Research Council's Metabolic Diseases Unit at Cambridge University.
Previous genetic variants associated with obesity have been linked to the brain pathways normally associated with appetite regulation, known as the leptin-melanocortin pathway, researchers said. Interestingly, neither the BSN nor the APBA1 gene are known to be involved in that brain pathway, researchers said. Instead, prior studies have found that these genes play a role in the transmission of signals between brain cells -- suggesting that age-related brain declines might affect appetite contro
Genetic Variants Obesity Risk APBA1 Gene Appetite Regulation Brain Pathways Signal Transmission Age-Related Brain Declines
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Newly Discovered Genetic Variants Could Increase Obesity Risk Six-Fold, Study SuggestsI'm a Texas native covering the latest trends in tech, science and healthcare through explainer pieces on the breaking news team. Previously, I was a Forbes HBCU Scholar writing under the innovation and health and science teams.
Read more »
YKT6 gene variants cause a new genetic disorder finds a new studyA recent collaborative study has discovered rare variants in the YKT6 gene as the cause of a new neurological disorder characterized by developmental delays along with severe progressive liver disease and a potential risk for liver cancer.
Read more »
Novel genetic variants associated with Alzheimer's diseaseA new study has identified 17 genetic variants that may influence Alzheimer's disease risk, putting researchers one step closer to uncovering biological pathways to target for future treatment and prevention.
Read more »
Rare Genetic Variants Are Curiously Connected With Being Left-HandedThe Best in Science News and Amazing Breakthroughs
Read more »
Genetic Testing of Some Patients With Early-Onset AF AdvisedCertain genetic variants may underlie atrial fibrillation alone, a ventricular cardiomyopathy or channelopathy syndrome, or both.
Read more »
Gene variants may protect against brain disease linked to cannibalismRemote tribes in Papua New Guinea were ravaged in the 20th century by kuru, which was spread when people ate their dead relatives as part of funeral rituals – but some individuals may have had genetic resistance to the condition
Read more »