Regions of the genome associated with Alzheimer's disease and dementia in African populations will be presented at the Future of Dementia in Africa conference on September 11-12, 2024.
Davos Alzheimer's CollaborativeSep 12 2024 Regions of the genome associated with Alzheimer's disease and dementia in African populations will be presented at the Future of Dementia in Africa conference on September 11-12, 2024. The studies highlight discrepancies compared to Caucasian populations and underscore that a lack of diversity in genomic studies potentially limits the effectiveness of targeted therapies across diverse populations.
ALS is a fatal type of motor neuron disease that can cause cognitive changes that can lead to symptoms of dementia. The team focuses on two common genetic causes of ALS and related disorders -; C9orf72 expansion and SOD1 mutation, which are currently the focus of trials for new treatments for ALS. They employed state-of-the-art long-read sequencing techniques to identify population-specific variants in these two genes.
Henry Houlden, Professor of Clinical Neurology at UCL, who was involved with both studies, said: "We are excited to share our data with researchers at the Future of Dementia in Africa conference, because people in African populations are underrepresented in research into dementia and other neurodegenerative conditions.
Genetics Alzheimer's Disease Amyotrophic Lateral Sclerosis Brain Education Genes Genetic Genome Genomic Medicine Mental Health Motor Neuron Disease Mutation Neurology Neuron Research Sclerosis
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