In the complex landscape of mental health research, a new peer-reviewed viewpoint offers a critical examination of how genes and environment conspire to influence schizophrenia risk. Published in Genomic Psychiatry (ISSN: 2997-2388, Genomic Press, New York), this thought-provoking analysis by researchers Natassia Robinson and Sarah E.
Genomic PressSep 11 2024 In the complex landscape of mental health research, a new peer-reviewed viewpoint offers a critical examination of how genes and environment conspire to influence schizophrenia risk. Published in Genomic Psychiatry , this thought-provoking analysis by researchers Natassia Robinson and Sarah E. Bergen from Karolinska Institutet in Stockholm, Sweden, brings together cutting-edge findings from genetics and epidemiology.
1. Polygenic risk scores for schizophrenia, while statistically significant, still have limited predictive power on their own. 4. New methodological approaches, including two-step designs and pathway-level analyses, offer promising avenues for future research. The authors stress the importance of large, well-characterized cohorts that combine genetic data with detailed information on environmental exposures throughout the lifespan. They also highlight the potential of emerging tools like family genetic risk scores and exposome-wide approaches to capture the full complexity of schizophrenia risk.
Schizophrenia Cannabis Epidemiology Gene Genes Genetics Genome Genomic Mental Health Psychiatry Research
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