The study identifies gut microbiome signatures during acute SARS-CoV-2 infection as predictors of long COVID, enhancing understanding of symptom variability.
By Vijay Kumar MalesuReviewed by Lily Ramsey, LLMDec 16 2024 A longitudinal study reveals that distinct gut microbiome profiles during acute SARS -CoV-2 infection can predict long COVID risk, offering insights into symptom clusters and potential biomarkers.
Background LC affects 10–30% of non-hospitalized individuals infected with SARS-CoV-2, leading to significant morbidity, workforce loss, and an economic impact of $3.7 trillion in the United States . Eligible individuals were contacted via email, and informed consent was obtained. Of the 1,061 participants initially recruited, 242 were excluded due to incomplete data, failed sequencing, or other issues. The final cohort included 799 participants , providing 947 stool samples.
Clinical data, including demographics, comorbidities, medications, and symptom persistence, were extracted from EHRs. The SARS-CoV-2-negative group was older, with higher antibiotic use and vaccination rates. These variables were adjusted for in subsequent analyses. Temporal analysis of gut microbiome changes between the acute and post-acute phases revealed significant individual variability but no cohort-level differences, suggesting that temporal changes do not contribute to LC development.
Coronavirus Encephalomyelitis Fatigue Machine Learning Myalgic Encephalomyelitis Research Respiratory SARS SARS-Cov-2 Severe Acute Respiratory Severe Acute Respiratory Syndrome Syndrome
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