Researchers have discovered a new way to target and kill cancer cells in hard-to-treat brain tumors using electrically charged molecules to trigger self-destruction, that could be developed into a spray treatment used during surgery.
A multidisciplinary team of researchers from the University of Nottingham, led by the School of Pharmacy found a new way to harness the extraordinary capabilities of bio-nanoantennae—gold nanoparticles intricately coated with specialized redox active molecules to induce programmed cell death, or apoptosis, in cancer cells on electrical stimulation. The research has been published today in Nature Nanotechnology.
The bio-nanoantennae were able to specifically target glioblastoma cells, leaving healthy cells unscathed. This unprecedented level of precision opens up new possibilities for developing treatment for Glioblastoma during surgical resection of the tumor, when the bionanoatennae would be sprayed or injected.
Dr Frankie Rawson led the research and explains: "The team showed that cancer cells succumb to the intricate dance of electrons, orchestrated by the enchanting world of quantum biology. With the advent of bio-nanoantennae, this vision of real-world quantum therapies edge closer to reality. By precisely modulating quantum biological electron tunneling, these ingenious nanoparticles create a symphony of electrical signals that trigger the cancer cells' natural self-destruction mechanism.
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