High-grade gliomas remodel neural circuits: promoting tumor progression and impaired cognition Nature UCSF gliomas glioblastoma tumor cognition neuroscience
By Neha MathurMay 9 2023Reviewed by Lily Ramsey, LLM In a recent study published in Nature, researchers attempted to investigate whether functional connectivity between glioblastoma and the brain affected cognition-regulating neural circuits and the survival of patients with high-grade glioblastomas.
A better understanding of these processes could help find therapeutic targets for gliomas, the most lethal type of malignant brain tumors. Next, the team conducted ribonucleic acid sequencing and mouse xenograft experiments using tumors of a subset of eight patients. High functional connectivity regions of glioblastoma comprise a molecularly distinct glioma subpopulation that differentially responds to neuronal signals, exhibiting an inherently proliferative and invasive profile.
These findings are well-aligned with the cancer biology principles that cell subpopulations take up distinct roles within the heterogenous cancer TME and functional connectivity measures could partially define these roles. Accordingly, patients with glioblastoma displayed functional connectivity between the tumor and the brain experienced an overall survival of shorter duration compared to non-HFC patients .
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