History of COVID-19 increases risk of fatigue and other long COVID symptoms in adults and children Children Coronavirus Disease COVID Fatigue medrxivpreprint WeillCornell CDCgov LPHIorg harvardmed
By Dr. Priyom Bose, Ph.D.Dec 21 2022Reviewed by Benedette Cuffari, M.Sc. Many individuals who have recovered from acute infection with the severe acute respiratory syndrome coronavirus 2 develop persistent symptoms collectively referred to as post-acute sequelae of the coronavirus disease 2019 or long COVID. Some common long COVID symptoms include fatigue, cognitive impairment, diabetes, shortness of breath, mental health conditions, cardiovascular diseases, and adverse kidney conditions.
More research is required to better understand new symptoms and conditions after recovery from SARS-CoV-2 infection. Most studies related to PASC have focused on specific patient populations, such as Medicare patients or United States veterans. Other studies that targeted the general adult population did not have a well-defined control group, thus minimizing the significance of these studies.
Relevant patient data was acquired from PCORnet between March 1, 2020, and May 31, 2020. A total of 3,091,580 adults above 20 years of age and 675,643 children younger than 19 years of age, who met all inclusion criteria, were included in this study. About 88% of the patients in this study were male and were relatively older, with a mean age of 59 years.
A significant difference in the prevalence of symptoms and incidence of conditions following COVID-19 was found between hospitalized and non-hospitalized groups. After adjusting for confounding factors, the hospitalized group with severe SARS-CoV-2 infection was at an increased risk of developing type 1 or 2 diabetes, hematologic disorders, and respiratory diseases. Notably, these outcomes were not observed among hospitalized patients who were negative for COVID-19.
An increased prevalence of certain conditions was reported among hospitalized adults who were negative for COVID-19, including major cardiovascular events, neurologic disorders, and mental health conditions.
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