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Researchers at the University of Colorado have discovered how bacteria in the gut convert dietary tryptophan into an inflammatory chemical that may contribute to arthritis, offering new insights for potential treatments. The study suggests that manipulating gut bacteria to alter tryptophan processing could provide a therapeutic pathway for rheumatoid arthritis and related conditions.
Many people think of tryptophan as the ingredient in turkey that supposedly makes us sleepy after a Thanksgiving feast. In fact,that although tryptophan plays a role in helping to regulate the sleep cycle, the amount that’s in turkey probably isn’t a significant cause of post-dinner drowsiness.
“We put mice on antibiotics to wipe out their microbiome, and they didn’t get arthritis, and they didn’t have indole,” she says. “So we said, OK, what if they do have a microbiome and we put them on a diet with little tryptophan? The microbiome can’t break down tryptophan into indole, and the mice didn’t get arthritis. So two different ways, we showed that it’s tryptophan that’s broken down by the microbiome into indole.
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