How B-cells and androgens contribute to the development of PCOS PCOS research Bcell AndrogenReceptor ImmunoglobulinM Autoimmune Comorbidities HormonalImbalance WomenzHealth eLife
By Hugo Francisco de SouzaJul 9 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in eLife, researchers use murine models to evaluate the role of B-cell frequencies in the pathogenesis of polycystic ovary syndrome .
PCOS is the most common hormonal disorder globally, affecting between 5-18% of women of reproductive age. Symptoms of PCOS include rapid weight gain, menstrual irregularity, excess hair growth, and acne. Importantly, PCOS is the most common cause of female infertility. Researchers began by characterizing B-cell lineages using 15 PCOS-positive and 22 PCOS-negative women as test and control groups, respectively. The test group fulfilled all three Rotterdam Criteria, which include polycystic ovarian morphology, amenorrhea, and hirsutism, in addition to exhibiting significantly higher androstenedione and testosterone levels.
To evaluate the role of androgens in B-cell composition and frequency, dihydrotestosterone -induced PCOS murine models were used. The three study groups included those subcutaneously administered DHT, controls, and mice receiving both DHT and an androgen receptor suppressor. Conclusions Hyperandrogenic women experience morphological and frequency variations in their B-cells, as well as an upregulation of circulating IgM in their blood and tissues. This is indicative of the role of androgens in PCOS onset; however, it does not discount the mechanistic influence of either B-cells or IgM.
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