45 drug-nutrient interactions (DNIs) that modify micro-nutritional status, particularly focusing on how acetylsalicylic acid (ASA) and warfarin may affect patients through various mechanisms.
By Dr. Sushama R. Chaphalkar, PhD.Mar 28 2024Reviewed by Lily Ramsey, LLM In a recent review published in Nutrients, researchers discussed 45 drug-nutrient interactions that modify micro-nutritional status, particularly focusing on how acetylsalicylic acid and warfarin may affect patients through various mechanisms.
These interactions include bio-inactivation, altered absorption, effect, or excretion. Medications may compete with micronutrients, induce physiological changes, or indirectly affect health. The American Institute of Medicine provides dietary reference intake recommendations for these nutrients and additional compounds, such as taurine and ergothioneine, essential for properly functioning longevity proteins.
Trace elements like iron may be affected, leading to an increased risk of anemia, while associated dietary compounds like taurine could potentially enhance ASA's antiplatelet effect and offer gastric protection. ASA's effects on mitochondrial oxidative phosphorylation raise concerns about the potential metabolic misuse of micronutrients, but the clinical relevance in humans requires further assessment.
Further, magnesium has been linked to stabilizing INR levels, potentially affecting warfarin therapy outcomes. Low vitamin K foods high in potassium may pose a risk for patients with chronic kidney disease due to hyperkalemia.
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