How does SARS-CoV-2 interact with other pathogens? ChariteBerlin SARSCoV2 COVID19 Pathogens Interactions
The survival of SARS-CoV-2 despite the widespread availability of effective vaccinations indicates that cocirculation with other viruses and the consequent multiepidemics may become more common. To better predict and limit the danger of such multiepidemics, it is crucial to clarify the potential connections between coronavirus disease 2019 and other infections. Yet, these interactions remain poorly understood.
Temporal dependency of interaction Time dependence is the second dimension of the suggested framework. Both the interval between infections and the order of infections can influence the manifestation and intensity of interaction. Owing to the dynamics of hormonal and cellular immune responses to respiratory infections, the degree of interaction between illnesses might fluctuate over time.
Throughout the 11 studies, three distinct animal models were utilized, and the experimental designs differed considerably, particularly in terms of the order of infection, the interval between infections, and the duration of follow-up. Nine research papers evaluated coinfections with IAV before SARS-CoV-2, six studies with SARS-CoV-2 before IAV, and five studies with simultaneous infections.
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