A Cleveland Clinic-led team of scientists and physicians have discovered that the immune checkpoint protein VISTA can directly turn off tumor-fighting T-cells during immunotherapy and resist treatment.
May 17 2024Cleveland Clinic
The findings from this study follow another discovery from the laboratory of Dr. Wang, Translational Hematology and Oncology that showed VISTA indirectly suppresses our immune systems by promoting cells called myeloid-derived suppressor cells that are well known to block T-cell function. Related StoriesThis project was a collaboration between labs led by Dr. Wang and Timothy Chan, MD, PhD, Chair of Cleveland Clinic's Center for Immunotherapy & Precision Immuno-Oncology, Director of the Global Center for Immunotherapy and Sheikha Fatima bint Mubarak Endowed Chair in Immunotherapy. The paper has four co-first authors: postdoctoral fellows Dr. Ta and Dia Roy, PhD; research associate Keman Zhang, PhD; and project staff Tyler Alban, PhD.
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