Increased TMPRSS2 expression in tongue tissue of females and alcohol drinkers identified as a potential risk factor for SARS-CoV-2 infection SARSCoV2 COVID19 coronavirus covid ACE2 tongue alcohol infection
By Dr. Chinta SidharthanOct 17 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in the Journal of Clinical Biochemistry and Nutrition, researchers explored the association between the expressions of angiotensin converting enzyme-2 receptor and transmembrane serine protease 2 in the tongue tissue and dysgeusia during severe acute respiratory syndrome coronavirus 2 infections.
About the study In the present study, the researchers used immunoblot analysis and immunohistochemistry techniques to determine ACE-2 and TMPRSS2 expression in the human and murine tongue tissue. Paraffin-fixed tissues were sectioned and mounted on glass slides. Immunostaining was performed using ACE-2 and TMPRSS2 antibodies. Tissues were homogenized and lysed using a lysis buffer after sonication, for the immunoblot analysis. Protein concentration was determined using a protein assay kit and sodium dodecyl sulfate-polyacrylamide gel electrophoresis . The immunoblots were incubated with ACE-2 and TMPRSS2 secondary antibodies conjugated with horseradish-peroxidase.
Additionally, the evaluation of ACE-2 and TMPRSS2 expression in other human organs revealed that ACE-2 expression is high in the kidneys, testes, and small intestine, whereas TMPRSS2 expression is upregulated in the breast tissue, liver, kidneys, and prostate gland.
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Lampard responds to Richarlison after Spurs ace claimed former club lacks ‘ambition’Frank Lampard’s love for Richarlison has seen the Everton manager give his former star a pass after comments about the Toffees’ apparent ‘lack of ambition’. The Tottenham man recently commented on …
Read more »
Jimmy Carr makes brutal dig at Amanda Holden's 'new face' in savage quipJimmy Carr made a savage dig at co-star Amanda Holden’s expense on BBC show I Can See Your Voice on Saturday night.
Read more »
Wittmann knew he was "not out of the game" amid DTM strugglesBMW star Marco Wittmann knew he was 'not out of the game' during his rough patch in the 2022 DTM season after finally returning to winning way at Hockenheim last weekend.
Read more »
Man Utd release statement after Mason Greenwood charged with attempted rapeMANCHESTER United released a statement tonight after Mason Greenwood was charged with attempted rape, controlling and coercive behaviour and ABH. The ace, 21, was suspended after spe…
Read more »
Increased TMPRSS2 expression in tongue tissue of females and alcohol drinkers identified as a potential risk factor for SARS-CoV-2 infectionIncreased TMPRSS2 expression in tongue tissue of females and alcohol drinkers identified as a potential risk factor for SARS-CoV-2 infection SARSCoV2 COVID19 coronavirus covid ACE2 tongue alcohol infection
Read more »