Inflammatory activity in rheumatoid arthritis impacts cognitive function

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Inflammatory activity in rheumatoid arthritis impacts cognitive function
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The inflammatory activity in the body caused by rheumatoid arthritis is linked to specific cognitive impairments, finds a small comparative study, published in the open access journal RMD Open.

BMJ GroupJul 29 2024 The inflammatory activity in the body caused by rheumatoid arthritis is linked to specific cognitive impairments, finds a small comparative study, published in the open access journal RMD Open.

To try and find out, the researchers compared the cognitive function of 70 adults with rheumatoid arthritis under the care of one hospital and 70 volunteers without rheumatoid arthritis, and matched for age, sex, and educational attainment. Specific cognitive abilities tested were: ability to process and order visuospatial information; naming; attention; language; abstract thinking; delayed recall; and orientation, plus executive functions of working memory, concentration, and inhibition.

In general, those who were cognitively impaired tended to be older, have lower educational attainment, and more coexisting conditions, such as obesity, unhealthy blood fat levels, and high blood pressure than those with intact cognition. Cognitively impaired patients had more substantial and persistent inflammatory activity than those patients who maintained their cognitive function. And they were more likely to have symptoms of depression and poorer physical capacity.

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