Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes

Traumaticbraininjury interferes with immune system cells' recycling process in brain cells, finds study ummedschool

Excessive and prolonged neuroinflammation following traumatic brain injury contributes to long-term tissue damage and poor functional outcomes. However, the mechanisms contributing to exacerbated inflammatory responses after brain injury remain poorly understood. Our previous work showed that macroautophagy/autophagy flux is inhibited in neurons following TBI in mice and contributes to neuronal cell death.

Defects in microglial and macrophage autophagy following injury were associated with decreased phagocytic clearance of danger/damage-associated molecular patterns responsible for activation of the cellular innate immune responses. Our data also demonstrated a role for precision autophagy in targeting and degradation of innate immune pathways components, such as the NLRP3 inflammasome.

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