Study reveals epigenetic vulnerability of acutemyeloidleukemia BCMHouston aacr
=6 . Fifteen weeks after transplantation, recipient mice were humanely euthanized, and lineage distributions of CD45.1 and CD45.2 peripheral blood cells were compared by flow cytometry.+leukemic cells in peripheral blood. Two weeks after engraftment, mice were assigned to treatment or control groups with essentially equivalent distributions of leukemic burden.
High-throughput sequencing data generated for this project have been deposited in the Gene Expression Omnibus database with SuperSeries accession numbers GSE205572 and GSE190723. Public H3K4me3 ChIP-seq data were analyzed from GEO accession No. GSM3681460.Consistent with previous reports, treatment of a panel of AML cell lines with BRM014 resulted in leukemic differentiation .
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