Using patient data from six major U.S. cancer centers, Brigham researchers and collaborators developed a risk prediction model for moderate-to-severe kidney injury after receiving the chemotherapy drug cisplatin in the largest, first generalizable study of its kind.
Mar 30 2024Brigham and Women’s Hospital
“Patients receiving treatment for cancer are increasingly affected by kidney injury, which is associated with higher mortality and can jeopardize eligibility for other therapies,” said first author Shruti Gupta, MD, MPH, director of Onco-nephrology at BWH and Dana-Farber and a physician in BWH’s Division of Renal Medicine.
Another key finding was that lower levels of magnesium were an important risk factor for acute kidney injury. The researchers plan to use the same rich database to try to identify therapies that might prevent kidney injury, including magnesium.
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