A ketogenic diet and reduced free sugar intake both lead to weight loss but have different effects on glucose tolerance, lipid metabolism, and the gut microbiome, with the ketogenic diet showing unfavorable metabolic changes.
By Dr. Liji Thomas, MDReviewed by Benedette Cuffari, M.Sc.Aug 7 2024 A recent study published in the journal Cell Reports Medicine compares the effects of a ketogenic diet with reduced free sugar intake on cardiometabolic health.
Carbohydrate restriction The ketogenic diet involves reducing carbohydrate intake for weight loss and altering one’s metabolism. These effects are attributed to the hepatic production of ketone bodies as fuel for peripheral tissues. Related StoriesThe ketogenic and low-free sugar groups reported consuming less than 8% and 5% of their total energy as carbohydrates, respectively. In the moderate-sugar group, 18% of energy was provided by free sugars.
Lipoproteins containing apolipoprotein B are responsible for the increased risk of atherosclerosis with higher cholesterol levels. Although apolipoprotein B levels increased in the ketogenic group, no change in total, LDL, or high-density lipoprotein cholesterol levels was observed at week 12.
Apolipoprotein Carbohydrate Cardiometabolic Cell Cholesterol Fasting Fatty Acids Fructose Glucose Ketogenic Diet Lipoprotein Medicine Metabolism Microbiome Muscle Phenotype Physical Activity Weight Loss
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