The association between midlife residential greenness and cognitive decline.
By Vijay Kumar MalesuReviewed by Lily Ramsey, LLMJul 22 2024 In a recent study published in the Environmental Health Perspectives, researchers investigated the association between midlife residential greenness and cognitive decline later in life, considering the effects of apolipoprotein E -ɛ4 status, socioeconomic status, and rural/urban residency.
However, most studies are cross-sectional. Midlife risk factors like psychological stress, vascular issues, and physical inactivity strongly influence dementia risk. The APOE-ɛ4 allele is a significant genetic risk factor. Of 22,715 eligible women, 92% participated initially, with over 90% continuing through three follow-ups until 2008. The analysis included 16,962 women with at least one cognitive assessment.
Interaction terms tested effect modification by SES, urbanicity, and APOE-ɛ4 status. Sensitivity analyses excluded participants with low baseline cognitive performance and recent movers and addressed changes. Higher midlife greenness exposure was consistently associated with higher baseline cognitive function, even after adjusting for individual and neighborhood-level covariates.
Participants with higher midlife greenness exposure experienced slower cognitive decline compared to those with lower exposure, consistent across buffer sizes and different NDVI measurements. However, there was no association between greenness and verbal memory decline.
Allele Antidepressant Apolipoprotein Brain Cognitive Function Dementia Genetic Mental Health Physical Activity Pollution Research Stress Vascular
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