Dexamethasone is one of the most important drugs in the treatment of severe COVID-19, but patients respond very differently to the therapy.
DZNE - German Center for Neurodegenerative Diseases Jul 3 2024 Research ers at the German Center for Neurodegenerative Diseases and Charité – Universitätsmedizin Berlin have now discovered how the cortisone compound influences the impaired inflammatory response and which patients benefit from it. Their method uses so-called single-cell analyses and raises hopes for a precise prediction tool for other therapies and diseases as well.
Monocytes indicate course of therapy At the beginning of the coronavirus pandemic, it became apparent that the immune system of people with a severe course of the disease often reacts excessively to the virus. They were therefore given dexamethasone, a cortisone derivative that is used to treat numerous diseases in order to influence the immune system. In many patients, treatment with dexamethasone resulted in rapid improvement.
The researchers were able to elucidate these processes with the help of single-cell sequencing. "This method allows for the individual characterisation of every single cell. Analysing cell signatures in such detail provides insights into the organism that were not possible just a few years ago", says Prof. Dr. Joachim Schultze, Director for Systems Medicine at DZNE and also one of the study's lead authors.
Dexamethasone Blood Cell Compound Coronavirus Cortisone Critical Care Diagnostics Drugs Immune System Infectious Diseases Medicine Monocyte Neurodegenerative Diseases Pandemic Research Virus
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