Hiroshi Abe and his team at Nagoya University have developed a novel method called Internal Cap-Initiated Translation (ICIT) that allows for precise control of protein synthesis in target cells. This breakthrough utilizes circular mRNA, known for its stability and reduced inflammatory effects, and introduces an internal cap structure to enhance translation efficiency. ICIT has the potential to revolutionize mRNA medicine by enabling the production of healthy proteins for treating diseases like Duchenne muscular dystrophy or toxic proteins for selectively killing cancer cells.
Nagoya UniversityFeb 19 2025 Imagine a breakthrough in cancer treatment where only malignant cells are targeted, sparing healthy host cells; or patients with abnormal protein synthesis are treated to produce a healthy protein. Hiroshi Abe and his colleagues at Nagoya University have identified two applications, among others, in a new study.
However, one significant challenge with circular mRNAs has been the inefficiency of their translation inside living organisms. Previous methods relied on long internal ribosome entry sites for introducing the mRNA, which were difficult to optimize and often inefficient. Abe's team overcame this hurdle by introducing a cap structure into the circular mRNA itself.
This technology is expected to revolutionize mRNA medicine, including antibody therapy, genome editing, and protein replacement therapy. Current mRNA is fundamentally unstable, requiring constant injections to be used for treatments such as protein replacement, a problem that our technique overcomes. Using this, we could treat diseases caused by abnormal protein synthesis, such as Duchenne muscular dystrophy.
Mrna Cancer Treatment Protein Synthesis Precision Medicine Circular Mrna
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