Researchers at the University of Liège have uncovered a previously unknown mechanism that regulates the immune response against parasites. During a parasitic infection, specific immune cells, known as virtual memory T cells (TVM), become activated and express a surface molecule called CD22, which prevents an excessive immune reaction. This discovery could help in better-controlling inflammation and improving immune responses to infections.
University of LiègeFeb 8 2025 Researchers at the University of Liège have uncovered a previously unknown mechanism that regulates the immune response against parasites. During a parasitic infection, specific immune cells, known as virtual memory T cells , become activated and express a surface molecule called CD22 , which prevents an excessive immune reaction. This discovery could help in better-controlling inflammation and improving immune responses to infections.
A surprising role for CD22 in T Cell regulation The researchers found that during helminth infections, a key immune molecule, interleukin-4 , strongly stimulates TVM cells, causing their proliferation in the spleen and lymph nodes. TVM cells are immune cells capable of reacting rapidly to viral infections. In a previous study published in 2018, the research team demonstrated that IL-4 stimulation of TVM cells enhances viral infection control during co-infections with helminths and viruses.
A delicate balance between defence and regulation This discovery opens up new perspectives on how the body regulates its immune responses. In addition to their role in combating certain infections, TVM cells activated during parasitic infections also help regulate inflammation. In other words, rather than merely responding to IL-4 produced during the infection, they also work to prevent an overreaction of the immune system.
IMMUNE SYSTEM PARASITES HELMINTHS INFLAMMATION CD22
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