A $5.8 million grant led by Adrie Steyn, Ph.D., of the University of Alabama at Birmingham and the Africa Health Research Institute, or AHRI, in Durban, South Africa, will provide user-requested infected human lung tissue and analytical services to tuberculosis researchers worldwide.
University of Alabama at BirminghamAug 23 2024
Today, with the emergence of antibiotic-resistant Mtb, "there are few studies focused on elucidating in humans the fundamental mechanisms of active, subclinical and latent TB," Steyn said. "We believe the TB field can no longer rely on animal models that yield findings of limited clinical relevance. Thus, there is an urgent need to better understand human pulmonary TB in order to develop clinically relevant therapeutic strategies.
Related StoriesIn the first year of the grant, researchers will create repositories of human TB lung tissue for analysis and dissemination at AHRI, as well as existing pulmonary and extrapulmonary TB specimens at UAB and the University of Texas Halth Science Center, Houston. These will come from active, subclinical and latent TB patients and decedents, along with clinical and radiological information.
Other analysis of human TB tissue will include immunohistochemistry and specialized stains, RNAscope to visualize individual mRNAs, spatial transcriptomics, and multiplex immunofluorescence. As part of their preliminary research, published in eBioMedicine this summer, Steyn and colleagues showed that the emerging technology, RNAscope, was able to identify Mtb mRNA in intact and disintegrating bacilli in tissues.
Tuberculosis Antibiotic Computed Tomography HIV Hospital Medicine Micro Microbiology Pathogen Pathology Ph Technology Tomography
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
What we know about the new mpox outbreak in AfricaA surging mpox outbreak in Africa, which was declared an emergency by the continent's health agency on Tuesday, is being driven by a new, more transmissible strain of the virus.
Read more »
New midwives from Africa hoping to draw on challenging experiences'It teaches you how to offer care with minimal commodities', said one midwife
Read more »
Lewis Hamilton backs new F1 grand prix in AfricaLewis Hamilton supports a plan to discuss a grand prix in Rwanda
Read more »
Hugely popular seaside theme park planning a big new expansion – including exciting new hotel...Prompt: Brighton Barry Island Tynemouth, North Tyneside Seahouses, Northumberland Folkestone St Mawes in Cornwall Mousehole in Cornwall St Andrews Gorleston beach Description: Discover the charm and beauty of some of the UK's most delightful coastal towns and beaches, from Brighton to Gorleston beach.
Read more »
‘Sensible’ approach calls for new homes in Chorley under new governmentChorley town hall The new government needs to take a “sensible” approach to how many houses should be built in places like Chorley, the borough’s coun
Read more »
Leeds United's next transfer set within new timeframes ahead of new seasonLeeds United have added four new faces to their squad in the summer transfer window and want to strengthen in midfield and full-back areas though Daniel Farke has talked down the urgency of those issues
Read more »