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A promising new medicine has now been introduced by an international team, led by researchers at the University of Texas. The nasal spray can bypass the blood-brain barrier and blast tangles of tau proteins in living mice. The drug also works at clearing tangles from within and between human neurons in the lab.
But that wasn't the only challenge. Researchers also had to figure out how to get the medicine past the blood-brain barrier and into the brain's cells. In aged mice with tau-associated brain disease, a single spray was all that was needed to clear toxic tau from the brain. Two weeks later, the mice showed improved cognitive functions.In a review of the findings for, University of Edinburgh neuroscientists Soraya Meftah, Claire Durrant, and Tara Spires-Jones, who were not involved in the current study,
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