A human cell culture model of the lung's most important immune cells, alveolar macrophages, helped make a key finding that is prompting researchers to rethink the role of another immune protein in infectious disease.
Texas Biomedical Research InstituteOct 10 2024 A human cell culture model of the lung's most important immune cells, alveolar macrophage s, helped make a key finding that is prompting researchers to rethink the role of another immune protein in infectious disease. The research was recently published in the journal Nature.
"It is exciting to see scientists around the world begin to use the AML model in their work and see how it can help reveal underlying mechanisms of the immune system that could change how we treat infectious diseases," said Larry Schlesinger, M.D., Texas Biomed Professor and President/CEO, who co-developed the AML model with Staff Scientist Susanta Pahari, Ph.D.
Experiments using the AML model, together with other cell models, helped confirm exactly why this is the case. Specifically, TNF is responsible for triggering the release of molecules called reactive oxygen species within alveolar macrophages to help kill off Mycobacterium tuberculosis, the bacterium that causes TB. When TNF is absent or blocked, ROS is not released and the bacteria are able to spread in the lungs.
For example, perhaps roles that have been attributed to TNF are being carried out by other molecules and could serve as new treatment targets for inflammatory disorders, stated a Rockefeller press release.
Alveolar Macrophage Bacteria Blood Cell Culture Cell Nucleus Genetic Infectious Diseases Lungs Macrophage Onion Protein Research Tuberculosis
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Northampton Market returns home after £10m faceliftThe historic market has new stalls from Italy, new paving, new lighting and new trees.
Read more »
Madonna, 66, unveils chiselled new look at New York Fashion WeekMadonna, 66, rocked New York Fashion Week wearing quite the outfit and looking super glamorous alongside stars like Beyoncé and Ice Spice.
Read more »
Delicious new menu at new Notts Greggs that's created 15 jobsThe new autumn menu includes an all-day breakfast and the Pumpkin Spiced Doughnut
Read more »
How new NHS staff guidance risks ‘policing’ new mothers over breastfeedingThe guidance looks set to reinforce the message that ‘Breast is Best’ - and questions mothers about why they are using formula.
Read more »
Cancer breakthrough as new vaccine ‘stops tumours in their tracks and prevents new disease’...Sun Health Explainer: What is cancer?
Read more »
New Brighton's New Palace and Adventureland Tops Seaside Heritage Network ListNew Brighton's iconic entertainment centre, New Palace and Adventureland, has been voted the top seaside destination in this year's Bucket and Spade List by the Seaside Heritage Network. The public vote highlighted the value of continuity and nostalgia in seaside experiences.
Read more »