An international team of researchers has identified new drug targets for therapies that could benefit patients with different forms of retinitis pigmentosa and other inherited retinal diseases.
University of Eastern Finland Oct 16 2024 Using advanced proteomics techniques, they unveiled shared critical pathways in retinitis pigmentosa disease models. The study represents significant progress in understanding how the proteome may change in different retinal dystrophies. Published in Molecular & Cell ular Proteomics, the study was carried out by researchers from the University of Eastern Finland , the University of California, Irvine, and the University of Ottawa.
Retinitis pigmentosa , a group of genetic disorders that cause progressive vision loss, has long been a challenge to treat due to its genetic diversity. However, the new study led by researchers at UEF suggests that disease-modifying treatments that could benefit patients with all forms of the disease, regardless of the underlying mutation, are achievable.
Better understanding of retinal proteins could accelerate the development of effective treatments This cross-institutional, multi-methodological study provided a comprehensive analysis of retinal proteins, comparing three mouse models of inherited retinal degeneration to healthy wild-type mice. Our data facilitate the development of new therapeutic strategies that do not rely on specific genetic mutations, potentially offering hope to millions of patients affected by retinal degenerative diseases.
"Additionally, we are sharing this detailed profile of retinal proteins in both healthy and diseased states with the scientific community to encourage further research and accelerate the development of effective treatments."Journal reference:Montaser, A. B., et al. . Retinal proteome profiling of inherited retinal degeneration across three different mouse models suggests common drug targets in retinitis pigmentosa. Molecular & Cellular Proteomics. doi.org/10.1016/j.mcpro.2024.
Genetic Proteome Proteomics Research Retinal Degeneration Retinitis Pigmentosa
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Northampton Market returns home after £10m faceliftThe historic market has new stalls from Italy, new paving, new lighting and new trees.
Read more »
New Brighton's New Palace and Adventureland Tops Seaside Heritage Network ListNew Brighton's iconic entertainment centre, New Palace and Adventureland, has been voted the top seaside destination in this year's Bucket and Spade List by the Seaside Heritage Network. The public vote highlighted the value of continuity and nostalgia in seaside experiences.
Read more »
Emmerdale discovery could reveal new Emmerdale baddie with new characters teased'It would be hard to marry the idea of a bad person in her life'
Read more »
New $3.26 million grant launches Undiagnosed Diseases Network site in New YorkA new four-year, $3.26 million grant from the National Institute of Neurological Disorders and Stroke (NINDS), a part of the National Institutes of Health (NIH), establishes the first Undiagnosed Diseases Network (UDN) site in the New York metropolitan area.
Read more »
Harvey Weinstein pleads not guilty to new sex crime charge in New YorkHarvey Weinstein has pleaded not guilty to a new sex crime charge during a court hearing in New York.
Read more »
Disgraced film producer Harvey Weinstein pleads not guilty to new sex crime charge in New YorkDisgraced film producer Harvey Weinstein has pleaded not guilty to a new sex crime charge in New York.
Read more »