Age-related macular degeneration (AMD) is the leading cause of vision loss in individuals over 65, characterized by abnormal changes in the macular, resulting in reduced vision and distorted objects.
National Research Council of Science & Technology Dec 23 2024 Age-related macular degeneration is the leading cause of vision loss in individuals over 65, characterized by abnormal changes in the macular, resulting in reduced vision and distorted objects. Dry AMD accounts for 90% of all AMD cases, with relatively mild vision impairment; however, approximately 30% progress to the severe vision loss associated with wet AMD within 10 years.
To address the limitations of injection-based treatments, the research team focused on the inflammatory signaling pathway of Toll-like receptors , which are known to play a critical role in AMD pathogenesis. By extracting peptide sequences from tens of thousands of proteins with structures similar to natural TLR signaling proteins, they established an extensive library of over 190,000 peptide drug candidates.
This new therapeutic agent, delivered in eye drop form, offers enhanced treatment convenience and adherence for patients while reducing complications and costs associated with repetitive invasive treatments. Furthermore, the non-invasive and safe nature of the therapy provides a novel treatment option that improves both efficacy and patient satisfaction. This innovation is expected to revolutionize the treatment accessibility of AMD and other related ophthalmic conditions.
Dr. Moon-Hyeong Seo, Natural Product Drug Development Center, Korea Institute of Science and Technology
Eye Macular Degeneration Drugs Efficacy Peptides Research Technology Vision Loss
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