Vaccinia viruses are therapeutic tools with different biomedical applications depending on the susceptibility characteristics.
May 24 2024University of Barcelona For example, the strain called MVA , which is unable to replicate in mammalian cells , triggers a potent immune system response and is used to develop vaccines against COVID-19 or AIDS . In contrast, other strains such as Western Reserve or Copenhagen , which replicate efficiently in tumour cells, are used to develop cancer treatments. For this reason, they are called immune-oncolytic viruses and are the basis of viral immunotherapy.
The study, published in the journal Molecular Therapy, has been carried out with the support of the Spanish Association Against Cancer and the collaboration of the State Research Agency . The new therapeutic tool, which has been tested in a wide variety of mouse models, has been shown to have reduced toxicity and a high capacity and efficiency to activate immune responses against tumours. The virus is also effective in different cancer treatments, such as melanoma, colon and kidney cancer.
Immunotherapy AIDS Cell Covid-19 Immune System Mammalian Cells Research Virus
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