One promising approach to treating Type 1 diabetes is implanting pancreatic islet cells that can produce insulin when needed, which can free patients from giving themselves frequent insulin injections.
Reviewed by Lily Ramsey, LLMSep 19 2023 However, one major obstacle to this approach is that once the cells are implanted, they eventually run out of oxygen and stop producing insulin.
While the researchers' main focus is on diabetes treatment, they say that this kind of device could also be adapted to treat other diseases that require repeated delivery of therapeutic proteins. Daniel Anderson, Study Senior Author and Professor, Department of Chemical Engineering, Massachusetts Institute of Technology
Related StoriesSome experimental devices, including one that has been tested in clinical trials, feature an oxygen chamber that can supply the cells, but this chamber needs to be reloaded periodically. Other researchers have developed implants that include chemical reagents that can generate oxygen, but these also run out eventually.
The researchers found that mice implanted with the oxygen-generating device were able to maintain normal blood glucose levels, comparable to healthy animals. However, mice that received the nonoxygenated device became hyperglycemic within about two weeks.
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