LMU researchers have investigated how cationic polymers organize on a molecular level when transporting RNA drugs.
Ludwig-Maximilians-Universitaet Muenchen Nov 27 2024
Cationic polymers are promising tools for transporting RNA therapeutics or RNA vaccines. Like lipid nanocarriers, they are used to deliver mRNA medicines. The nanoscopic packaging materials are able to effectively protect their load and deliver them to the target cells. We manufacture so-called 'gene ferries,' into which all kinds of therapeutic nucleic acids can be encapsulated for secure transport to the site of action." To further improve the effectiveness of these gene ferries, however, it is important to understand how these particles organize on a molecular level, encapsulate RNA, and release it again - an aspect which so far has not been fully examined.
"Our research used a technique called coarse-grained molecular dynamics to simulate and visualize the particles," explains Merkel. The specific focus was on how changes in polymer structure and environmental conditions impact particle formation. Simulations were supported by wet lab experiments using nuclear magnetic resonance , which confirmed that CG-MD can reveal detailed insights into the structure and behavior of RNA nanoparticles.
Research Drugs Polymers RNA Therapeutics
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