Neuroscientists from Johns Hopkins Medicine say they have determined how a brain cell surface molecule shapes the way certain neurons behave.
Johns Hopkins Medicine Oct 3 2024
Until now, the role of these specific receptors in the wider mammalian brain as it functions in everyday life has been a mystery." Along with Hong, the research was led by Richard Huganir, Ph.D., Bloomberg Distinguished Professor of Neuroscience and Psychological and Brain Sciences and director of the Solomon H. Snyder Department of Neuroscience at the Johns Hopkins University School of Medicine, who has been studying AMPA receptors for more than 40 years.
The researchers also found that mutations of GluA2, a protein subunit within the CP-AMPA receptor, are associated with intellectual disabilities. To conduct their research, the scientists developed novel adeno-associated virus vectors to replace calcium permeable AMPA receptors with impermeable counterparts and express them in the mouse brain. They say they hope these vectors can help treat disorders that arise from AMPA receptor mutations in the future.
The researchers say the high amount of CP-AMPA receptors in PV neurons is well-conserved across many species of mammals, including humans.
Molecule Neurons Autism Brain Cell Calcium Cell Cortex Epilepsy Hippocampus Machine Learning Medicine Neuron Neuroscience OCT Ph Receptor Research Schizophrenia
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