Antibiotic exposure shows potential protective effects against Parkinson's, while antifungal use is linked to increased risk, indicating microbiome involvement.
By Vijay Kumar MalesuReviewed by Lily Ramsey, LLMOct 28 2024 Large study reveals surprising links between common antibiotics, antifungal treatments, and Parkinson’s risk—could certain medications offer protection?
Research shows that aggregated alpha-synuclein can propagate from the gut to the brain via the vagus nerve, triggering inflammation and neuronal loss. Recent studies suggest that antimicrobial use alters gut microbiome diversity, potentially increasing PD risk. In the UK, antibiotics are exclusively available through prescriptions, enhancing the reliability of the data for drug safety research. The study received approval from both the Rutgers Institutional Review Board and the CPRD Independent Scientific Advisory Committee.
Study results The study included 12,557 PD cases and 80,804 matched control subjects. The median follow-up time was 26.0 years 17.4-40.4) for PD cases and 25.3 years for controls. Similarly, the OR was 0.84 for 6-10 years prior and 0.87 for 11-15 years prior. The number of macrolide courses also showed an inverse association with PD risk during the 1-5 year exposure period, though this was not statistically significant .
Antifungal Brain Dysbiosis Genetic Inflammation Microbiome Nerve Parkinson's Disease Penicillin
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