A team led by the Cancer Immunogenomics group at the Josep Carreras Leukaemia Research Institute, the Computational Biology group at the Barcelona Supercomputing Center and the Germans Trias i Pujol Research Institute shows, for the first time, that within a tumor, the expression of the different hallmarks of cancer is not cell-specific, but...
Josep Carreras Leukaemia Research InstituteJan 30 2025 A team led by the Cancer Immunogenomics group at the Josep Carreras Leukaemia Research Institute, the Computational Biology group at the Barcelona Supercomputing Center and the Germans Trias i Pujol Research Institute shows, for the first time, that within a tumor, the expression of the different hallmarks of cancer is not cell-specific, but rather position-specific.
To answer these questions, Dr. Eduard Porta, principal researcher of the Cancer Immunogenomic laboratory at the Josep Carreras Leukaemia Research Institute and researcher of the Computational Biology group at the Barcelona Supercomputing Center – Centro Nacional de Supercomputación , led a team of renowned scientists, including Dr. Esteller , Dr. Barretina , Dr. Real and Dr. Bailey .
Furthermore, it seemed that hallmarks may influence each other, and the position of ones can be predicted by the presence of others, using machine learning algorithms. This would be a disruptive vision on tumor evolution, moving from a selection-based paradigm to an ecological perspective where function, expressed in terms of hallmarks, could be the golden rule.
Tumor Cell Genetic Genomics Malignant Research
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