Scientists have discovered 17 additional genes that drive the abnormal overgrowth of mutated blood cells as we age. The findings, published today (14 May) in Nature Genetics, provide a more complete view of the genetic factors behind clonal hematopoiesis – a process associated with ageing and linked to increased risks of blood cancers.
May 15 2024The Wellcome Sanger Institute Scientists have discovered 17 additional genes that drive the abnormal overgrowth of mutated blood cells as we age. The findings, published today in Nature Genetics , provide a more complete view of the genetic factors behind clonal hematopoiesis – a process associated with ageing and linked to increased risks of blood cancers.
By uncovering these previously unrecognized genetic drivers, the research opens new avenues for studying the molecular mechanisms underlying clonal hematopoiesis and its role in disease development, leading to new ways to promote healthier ageing. Additionally, it could lead to better genetic tests that help identify the risks of blood cancers and cardiovascular diseases.
Researchers set out to map characteristic patterns of positive selection in the ageing blood system, leveraging whole exome sequencing data from over 200,000 individuals in the UK Biobank cohort. They identified 17 genes driving the accumulation of mutant cell clones in our blood, beyond the known set of drivers.
Blood Genes Hematopoiesis Cell Genetic Genetics Research UK Biobank
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