Some patients with diabetes develop a serious condition known as diabetic cardiomyopathy, which is slow and cannot be directly attributed to hypertension or other cardiovascular disorders.
University of BarcelonaDec 12 2024 This often under-diagnosed heart function impairment is one of the leading causes of death in diabetic patients and it affects both type 1 and type 2 diabetes . There is no current specific drug treatment or clinical protocol approved to address this disease.
Other researchers signing this paper are Fátima Crispi, from the UB's Faculty of Medicine and Health Sciences, BCNatal and the Centre for Biomedical Research Network on Rare Diseases ; Francisco Nistal, from the University of Cantabria and the Marqués de Valdecilla University Hospital and the Centre for Biomedical Research Network on Cardiovascular Diseases , and Walter Wahli, from the University of Lausanne , among other experts.
Many of the PPARβ/δ-regulated genes are involved in lipid and glucose metabolism. This protein is linked to metabolic diseases with an inflammatory background: for example, insulin resistance induced by obesity or diabetes, dyslipidaemia or metabolic fatty liver disease ." "Most of these pathologies are associated with a decrease in the transcriptional activity of PPARβ/δ and, in fact, it has been suggested that its activation could be useful to treat them.
How does the PPARβ/δ protein act in diabetic cardiomyopathy? To date, it was known that activation of PPARβ/δ in the heart could prevent metabolic dysregulation during diabetes and obesity. This would help prevent heart failure, the inability of the heart to pump blood efficiently to all organs and tissues in the body.
Heart Disease Adipose Apoptosis Biomedicine Blood Cardiomyopathy Cell Cell Death Diabetes Fatty Acids Fibrosis Food Glucose Heart Failure Hospital Hyperglycaemia Inflammation Insulin Insulin Resistance Liver Metabolism Muscle Obesity Pharmacy Protein Receptor Research Type 2 Diabetes
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