Carbonic anhydrase inhibitors show potential in reducing tau protein buildup, offering new therapeutic avenues for neurodegenerative diseases like tauopathies.
By Dr. Chinta SidharthanReviewed by Lily Ramsey, LLMNov 4 2024 Carbonic anhydrase inhibitors show promise in reducing tau protein buildup and neurodegeneration, paving the way for new treatments in neurodegenerative diseases .
Background Tauopathies are a group of neurodegenerative diseases caused by the accumulation of tau proteins inside brain cells. They include diseases such as corticobasal degeneration and progressive supranuclear palsy. However, despite the high prevalence of various neurodegenerative diseases associated with toxic tau build-up, effective pharmacological treatments have been lacking. Furthermore, many of the previous drug screens have been conducted in cell cultures, which do not fully replicate the complexity of the brain.
Of these compounds, 94 lethal ones were excluded, and the researchers used Western blot analysis to measure the degree of rod degeneration post-treatment by analyzing the ratio of rhodopsin to arrestin, which would indicate the survival of rod cells. They also used clustered regularly interspaced short palindromic repeats /CRISPR-associated protein 9 to target the genes encoding carbonic anhydrase to determine whether the knockdown of specific carbonic anhydrase isoforms would also reduce tau-associated degeneration.
Cas9 Cell Chemicals Corticobasal Degeneration CRISPR Drugs Gene Genes Genetic Glaucoma Neurodegeneration Neurodegenerative Diseases Progressive Supranuclear Palsy Protein Tau Protein
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Clinical utility of carbonic anhydrase IX in diagnosing pleural mesotheliomaMesothelioma is an aggressive tumor with a poor prognosis. Histological diagnosis of mesothelioma using limited tissue samples can be challenging.
Read more »
Carbonic anhydrase inhibitors clear tau build-up in zebrafish models of tauopathiesA drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein tau, which causes various forms of dementia and is implicated in Alzheimer’s disease.
Read more »
Big Brother hosts' plan shake-up in new season with 'new rules' and twistsWill Best and AJ Odudu plan to spice up the rules for the new series if the show - teasing a huge shake-up.
Read more »
New Zealand 31-49 England: Clinical Red Roses hammer New Zealand at WXVEngland produced a clinical attacking display in a nine-try win over New Zealand to move closer to retaining their WXV1 title in Canada.
Read more »
Tuesday the new Monday, according to new researchIt’s official, Tuesday is the new Monday, as seven out of 10 Brits feel the days have switched because so many of us work from home at the start of the week
Read more »
Waterfront English town reveals £51million transformation – with new hotels, New York-style park and food m...English town reveals new £51million plans including new hotels, trainline park and ‘garden village’
Read more »