Variants of the PER3 gene disrupt adrenal adaptation to winter light, leading to serotonin disruption and depression-like behaviors in humanized mice models.
By Hugo Francisco de SouzaReviewed by Lily Ramsey, LLMNov 13 2024 Findings suggest that PER3 gene variants prevent adrenal adaptation to winter daylight, leading to serotonin disruption and depression-like behaviors.
Study background Several human physiological processes and clinical conditions exhibit seasonal rhythms, often linked to increases in pathogen or vector populations or changes in environmental cues . About the study In their previous work, the present study group identified genetic variants of the PERIOD3 gene that demonstrate advanced sleep patterns and seasonal mood alterations reminiscent of SAD. Called 'P415A' and 'H417R', these variants could hold the key to understanding SAD and form the basis of future therapeutic interventions against the debilitating condition.
Fluoxetine hydrochloride functions as a serotonin uptake inhibitor and helps reveal the importance of neurotransmitter concentrations and signaling under these conditions.
Gene Corticosteroid Corticosterone Genetic Glucocorticoid Metabolism Pathogen Research Serotonin Tryptophan
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