Researchers at the University of Bern and Bern University Hospital have developed a test to simplify the diagnosis of allergies.
University of BernOct 15 2024 Its effectiveness has now been confirmed in clinical samples from children and adolescents suffering from a peanut allergy . The results could fundamentally improve the clinical diagnosis of allergies in future.
A team of researchers led by Prof. Dr. Alexander Eggel from the Department for BioMedical Research at the University of Bern and the Department of Rheumatology and Immunology, Bern University Hospital, and Prof. Dr. Thomas Kaufmann from the Institute of Pharmacology at the University of Bern, developed an alternative test in 2022. It mimics the allergic reaction in a test tube and thus offers an attractive alternative to standard tests.
In the Hoxb8 mast cell activation test , which we developed, mast cells grown in the laboratory are brought into contact with blood serum from allergic patients. The mast cells bind the IgE antibodies from the serum and are sensitized by them. We can then stimulate the mast cells with different amounts of the allergens to be tested." Quantifying the activated mast cells suggests how allergic a patient is to the allergen tested without needing to consume the food.
Allergen Allergy Antibodies Blood Blood Test Cell Children Diagnostic Food Hospital Immunology Laboratory Mast Cell Peanut Allergy Research Skin Stress Technology
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