Newly discovered barrier prevents immunity from reaching smell-sensing cells ImmunityCP
and rapidly replicates, reaching the olfactory bulb of the brain within a day. Although it can lead to paralysis and death, it is usually cleared by a T cell response., and when it can do that, it will get into the brain," Moseman said."Even if you have antibodies in circulation, the blood-olfactory barrier prevents these antibodies from reaching the airway surface, and VSV will get into the brain.
to enter olfactory tissues and locally produce neutralizing antibodies. The findings appear Sept. 21 in the journalThe researchers weren't looking at this question because of COVID, but the SARS-CoV-2 virus is known to infect olfactory cells and causein many infected individuals.
"You could have a situation where you have perfectly good antibody in circulation from a COVID vaccination, but these antibodies are prevented from reaching the olfactory cells," Moseman said."You'd be protected against severe pulmonary disease, which is great, but you could still have these replicating events going on in the olfactory epithelium because the systemic antibody doesn't get there.
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