NIH supports research to understand the genome-metal interactions in nonalcoholic fatty liver disease

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NIH supports research to understand the genome-metal interactions in nonalcoholic fatty liver disease
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Wanqing Liu, Ph.D., professor of pharmaceutical sciences in the Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences and of pharmacology in Wayne State's School of Medicine, received a $3 million, five-year award from the National Institute of Environmental Health Sciences of the National Institutes of Health.

Reviewed by Lily Ramsey, LLMAug 21 2023 The study, "Interaction between Genome and Heavy Metals in Nonalcoholic Fatty Liver Disease," aims to discover and validate the gene Х heavy metal interactions in human livers and to understand their role in nonalcoholic fatty liver disease .

NAFLD is the most common chronic liver disease, affecting more than 30% of the U.S. population. NAFLD is characterized by a spectrum of histological changes with multiple cells involved. There are no approved drug treatments available currently for the disease. Wanqing Liu, Ph.D., professor of pharmaceutical sciences in the Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences and of pharmacology in Wayne State's School of Medicine

"By leveraging our previously collected data, we have begun to identify numerous metal-response genes, expression quantitative traits loci and allele-specific expression loci, which are further enriched to NAFLD and its related pathways," said Cassidy-Bushrow. "We aim to expand our study to a large-scale, highly detailed and integrated analysis to thoroughly understand the role of GXM interactions in NAFLD in humans.

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