A new study from Chiba University reveals a compound, V-161, that effectively inhibits the growth of vancomycin-resistant Enterococcus faecium (VRE) by targeting a sodium-pumping enzyme crucial for bacterial survival. This breakthrough offers hope in the fight against antibiotic resistance, a growing global threat.
Chiba UniversityJan 23 2025 V-161, a novel compound targeting the Na+ -V-ATPase enzyme in vancomycin-resistant Enterococcus faecium , significantly reduces bacterial growth and colonization. A recent study has demonstrated a promising approach for fighting antibiotic resistance by identifying a compound, V-161, that inhibits a sodium-pumping enzyme critical for VRE survival under alkaline conditions in the intestine while preserving beneficial bacteria.
In response to this crisis, a team of researchers led by Professor Takeshi Murata from the Graduate School of Science, Chiba University, Japan, has discovered a promising new compound, V-161, which effectively inhibits the growth of VRE. Their research examined a sodium-pumping enzyme found in these bacteria called Na+-transporting V-ATPase found in E. hirae, a close relative of E. faecium, used as a safer, more tractable model for studying the enzyme.
A major finding of this study was the high-resolution structural analysis of the membrane V0 domain of the enzyme, revealing detailed insights into how V-161 binds to it and disrupts the enzyme function. V-161 targets the interface between the c-ring and the a-subunit of the enzyme, effectively blocking sodium transport. This structural information is critical to understanding the workings of the compound and provides a foundation for developing drugs that target this enzyme.
Health ANTIBIOTIC RESISTANCE VRE Na+-V-Atpase NEW COMPOUND DRUG DEVELOPMENT
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