A new preclinical study by Mass Eye and Ear investigators showed that a novel mRNA-based therapy may be able to prevent blindness and scarring from proliferative vitreoretinopathy (PVR) following a retinal detachment repair or traumatic injury to the eye.
Mass Eye and Ear Nov 27 2024 A new preclinical study by Mass Eye and Ear investigators showed that a novel m RNA -based therapy may be able to prevent blindness and scarring from proliferative vitreoretinopathy following a retinal detachment repair or traumatic injury to the eye. There is no current treatment for PVR other than surgery, which itself carries a high risk of causing or exacerbating PVR.
In the new paper, the researchers detail preclinical studies using mRNA as a therapeutic in the eye. Messenger RNA, or mRNA, is an essential part of every single cell in the body. Cells copy the code of genes into pieces of RNA and these RNAs act as messengers that ferry the genetic codes to the ribosomes, which use it to create proteins. Strands of mRNA can code for any protein -; even ones not in the cell's genome.
The investigators initially believed that targeting RUNX1 was the best approach, but current technologies were limited. mRNA is primarily used to increase protein expression, whereas the issue in PVR was excessive RUNX1. A key insight for developing this new experimental therapy was the idea of creating a molecule that would trap RUNX1 and inhibit its function-;a strategy known as a dominant-negative inhibitor in biology.
Eye Preclinical Blindness Blood Blood Vessels Cell Gene Genes Genetic Inflammation Medical School Medicine Neck Ophthalmology Protein Research Retinal Detachment RNA Scar Surgery Technology Throat Trauma
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