Extended-release ketamine tablets taken twice weekly was effective for treatment-resistant depression with fewer side effects compared with intravenous or intranasal ketamine in a phase 2 trial.
In the trial, twice weekly dosing of extended-release ketamine led to statistically significant and clinically meaningful improvement in depressive symptoms.
Several small studies have shown that ketamine still works as an antidepressant when taken orally, although it still produces some dissociation. The study met its primary objective, with the 180-mg R-107 group demonstrating a significant reduction in MADRS scores compared with placebo (mean difference, -6.1;Seventy-one percent of patients in the placebo group experienced a relapse into depression after 13 weeks compared with 43% of patients who received twice weekly oral ketamine.
"In addition, the researchers demonstrated a major upside of oral ketamine — that side effects did not separate significantly from placebo," Keedwell said.
Adverse Effects Side Effects Antidepressant Antidepressant Drug Patient Safety Intravenous IV - Intravenous Intravenous Route Blood Intravenous Anesthetic Intravenous Anesthetic Agent Intravenous Anaesthetic Intravenous Anaesthetic Agent Increased Blood Pressure Sedation Sedative Sedative Use Anesthesia Anesthetic Anesthaesia Anaesthetic Anxiety Dizziness Fellowship
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Hello Kitty Partners With Moon Oral Beauty for a New Oral Care Collection: Shop NowHere's where to buy the Hello Kitty and Moon Oral Beauty Collection online.
Read more »
Matthew Perry and the ketamine boom: Expensive, dangerous and very 'en vogue'In recent years, ketamine prescriptions have increased along with a black market business for those self-medicating or using the drug recreationally.
Read more »
The ketamine boom: How the wealthy are getting their hands on the in-demand drugMedical and law enforcement officials say the wealthy are financing the ketamine black market while more prescriptions and specialized clinics are emerging.
Read more »
Utah’s lethal injection cocktail will include ketamine, fentanylUtah will include ketamine and fentanyl in its three-drug lethal injection cocktail — a combination that a death row inmate's attorney argues are 'experimental' and 'untested.'
Read more »
Kenya Moore reacts to her RHOA suspension after allegedly sharing posters of costar performing oral sexKenya Moore has responded to reports of her being indefinitely suspended from 'The Real Housewives of Atlanta' for revealing posters of Brittany Eady allegedly performing oral sex during filming.
Read more »
Oral Tranexamic Acid Boosts Melasma Outcomes With Topical Combination CreamOral tranexamic acid added to triple combination cream therapy improves melasma outcomes.
Read more »