Oral tranexamic acid added to triple combination cream therapy improves melasma outcomes.
A meta-analysis showed that the use of oral tranexamic acid along with the standard triple combination cream reduces melasma severity and recurrence in patients with melasma, without increasing toxicity.Current treatments for melasma focus on inducing remission and preventing relapse. Tranexamic acid, an antifibrinolytic drug, has shown promise in recent studies, but its optimal use, either alone or as an adjunct to TCC, remains unclear.
Researchers conducted a meta-analysis of four randomized controlled trials patients that compared oral tranexamic acid plus TCC and TCC alone in 480 patients with melasma, divided almost evenly into the two treatment groups. The main outcome was the change in the Melasma Severity Area Index score and recurrence rate from baseline.Patients treated with oral tranexamic acid plus TCC showed a greater reduction in MASI scores compared with those who received TCC alone and burning , and timing of treatment.
Toxicity Poisoning Toxins Melasma Chloasma Meta-Analysis Antifibrinolytics Burns Multiple Sclerosis Multiple Sclerosis MS MS - Multiple Sclerosis Remission Wound Management Wound Care
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