A scientific team supported by the National Institutes of Health (NIH) has created a preclinical blood test to identify adults most likely to develop severe respiratory conditions, including chronic obstructive pulmonary disease (COPD).
NIH/National Heart , Lung and Blood InstituteSep 10 2024 A scientific team supported by the National Institutes of Health has created a preclinical blood test to identify adults most likely to develop severe respiratory conditions, including chronic obstructive pulmonary disease . The blood test analyzes 32 proteins that scientists determined accurately predicted an adult with an increased likelihood for requiring medical care for or dying from severe respiratory illness.
To create the risk score, investigators first reviewed lung health data collected from 2,470 adults, ages 18-30, who participated in a 30-year cardiovascular health study. They then screened thousands of proteins from blood samples provided by participants at the 25-year mark and selected 32 that best predicted which participants were having a rapid decline in lung function.
Loss of lung function on a year-over-year basis is associated with poor respiratory health outcomes, but we do not have a good way to easily figure out if a patient is on a steep trajectory of lung function decline. If we had an easy-to-implement clinical tool, like a blood test, that captured someone's lung function trajectory at a single time point, it would enable earlier interventions which might, in the long run, improve lung health.
Participants in the decades-long study took breathing tests to measure their lung function -; up to six times throughout the study -; and generated other lung health data. Throughout this period, 2,332 participants experienced a normal decline in lung function and 138 experienced a sharp decline.
Blood Test Respiratory Breathing Chronic Chronic Obstructive Pulmonary Disease Critical Care Heart Medical Research Medicine Ph Preclinical Research Respiratory Disease Respiratory Illness Smoking
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