A deeper understanding of the communication inside the body when someone is going through opioid withdrawal has led to a new clinical trial at the University of Calgary.
University of CalgaryAug 29 2024
"The area of the brain that is sending the signal regulates the autonomic system, our fight-or-flight response," says Trang, principal investigator on the study recently published in Nature Communications. "During withdrawal that centre in the brain is hyperactive contributing to the body's reaction during withdrawal."
Montgomery says anyone can become physically dependent on opioids within a couple of weeks and they need to taper to stop use of the drug. She adds Canada is the highest prescriber of opioids in the world. Montgomery, an associate professor at the Cumming School of Medicine , is recruiting people for a clinical trial using a safe, well tolerated drug for gout, probenecid, to help with the disabling symptoms of opioid withdrawal.
Clinical Trial Chronic Chronic Pain Gout Headache Medicine Nausea Nervous System Opioids Pain Research Veterinary
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