The strain-specific effects of Lactobacillus rhamnosus GG (LGG) in preterm infants through a systematic review and meta-analysis of randomized controlled trials (RCTs) and non-RCTs.
By Vijay Kumar MalesuReviewed by Lily Ramsey, LLMJul 31 2024 In a recent study published in the European Journal of Clinical Nutrition , a group of researchers assessed the strain-specific effects of Lactobacillus rhamnosus GG in preterm infants through a systematic review and meta-analysis of randomized controlled trials and non-RCTs.
Further research is needed to determine the optimal strain, duration, dose, and safety of probiotics for preterm infants, as the effects are strain-specific and current data show significant heterogeneity. The search spanned the Cochrane Central Register, Excerpta Medica database , PubMed, and Cumulative Index of Nursing and Allied Health Literature databases, with no restrictions on design or language.
Statistical heterogeneity was evaluated with the χ2 test and I2 statistic. Trial sequential analysis and subgroup analyses were conducted, and findings were summarized according to GRADE guidelines.Study results The literature search retrieved 1,435 potentially relevant citations. After excluding 995 duplicates and 331 studies that did not meet inclusion criteria, 24 RCTs and eight non-RCTs were included. 11 RCTs studied single-strain LGG, while the remaining 13 used multi-strain probiotics.
7 multi-strain probiotic RCTs had low ROB for random sequence generation, allocation concealment, and intervention blinding. Non-RCTs were assessed using the Newcastle Ottawa scale, with seven studies scoring eight and one scoring seven.
Necrotizing Enterocolitis Probiotic Birth Weight Hospital Intestinal Disease Lactobacillus Mortality Nutrition Probiotics Research Sepsis
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