Programmable DNA-Based Synthetic Consensates condensates DNA synthetics materials ScienceMagazine
By Bhavna KavetiOct 31 2022Reviewed by Susha Cheriyedath, M.Sc. Nevertheless, realizing such systems with predictable organization and desirable functions remains challenging.
Concentrating specific reaction components enabled synthetic condensates to expedite logic gate operations and DNA strand displacement reactions. Thus, DNA-based condensates helped achieve the high-order functionalities required to create life-like artificial systems. As a building block, DNA has distinct advantages over all other known materials because of its specific intermolecular interactions and thermodynamic stability, which can be precisely determined from its linear sequence.
Watson-Crick base pairing-based biomolecular phase separation has been linked to the formation of intracellular condensates and has also been demonstrated with DNA nanostructures of restricted valency, known as DNA nanostars. The current study showed that preferential partitioning and enrichment of clients in condensates significantly expedited displacement reactions in DNA strands, a property used in molecular computation. Thus, the DNA condensates in this study offered a programmable platform in which their function and composition can be predicted.
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