Research highlights the potential risk of secondary SARS-CoV-2 transmission from wild rats Research SARSCoV2 Coronavirus Disease COVID NorwayRats Rats Zoonosis mbio ASMicrobiology
In addition to humans, SARS-CoV-2 can infect various domestic, wild, and captive animals, including cats, dogs, deer, ferrets, gorillas, lions, mink, otters, tigers, and others. The virus has evolved rapidly, and several genetic variants have emerged. SARS-CoV-2 variants acquired mutations in the spike protein’s receptor-binding domain that reportedly facilitate infectivity in rats/mice.
The study and findings In the present study, researchers evaluated rat exposure to SARS-CoV-2 in NYC. They conducted surveillance between September 13 and November 21, 2021, when SARS-CoV-2 Delta was predominant in the city. Seventy-nine rats were captured/sampled from three sites in Brooklyn, NYC. Phylogenetic analyses and molecular characterization suggested the sequences were associated with SARS-CoV-2 lineage B. Next, the team investigated whether SARS-CoV-2 variants could infect rats. Six-week-old rats were intranasally challenged with SARS-CoV-2 Alpha, Delta, or Omicron. Lung tissues and turbinates were harvested at 2 and 4 days post-infection .
Immunology eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Further, immune responses to infection were determined by measuring the expression of cytokines/chemokines at 2 and 4 dpi and antibodies at 21 dpi. All variant infections elicited a pro-inflammatory expression profile, particularly at 2 dpi. Consistently, Delta-infected rats had the highest expression. IgG and nAbs were detectable against all variants at 21 dpi.
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